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Next-generation Technology for Focal Prostate Cryotherapy

Tuesday, April 10, 10:30-12:00
Meridian Ballroom 1, Graduate Minneapolis

Organizer: John Bischof, Mechanical and Biomedical Engineering, University of Minnesota

"MRI-Ultrasound Fusion Based Focal Cryosurgery"
Rajesh Venkataraman, R&D Manager, Eigen

"The Possibility of Focal Cryoablation of the Prostate Under MR Image Guidance"
Satish Ramadhyani, Technical Lead, Systems Engineering, Galil Medical

"Focal Cryotherapy of Localized Prostate Cancer: A Work in Progress"
Franz Schmidlin, Head of Urology, Clinique des Grangettes

"Computation Tools in the Service of Cryotherapy"
Yoed Rabin, Mechanical Engineering, Carnegie Mellon University

"Adjuvants and Immunotherapy in Cryotherapy"
John Bischof, Mechanical and Biomedical Engineering, University of Minnesota


Session Abstract:

Cryosurgery is a probe-based focal technique that uses cryogenic temperatures to destroy diseased tissues within the body for therapeutic benefit. This session will focus specifically on the use of cryosurgery for the destruction of prostate cancer and highlight new technologies that are available or under development to enhance this approach. Specific highlights of the session will include improvements to cryosurgical device technology, improved image guidance, computational planning and education tools, enhanced destruction and control with adjuvants, and a review of current clinical practice. At the end of the session, the audience will have gained an understanding of current cryosurgical practice as well as future application with next-generation technologies.


Speaker Bios:

Rajesh Venkataraman, R&D Manager, Eigen
Rajesh Venkataraman works as the head of R&D at Eigen that develops medical devices for MRI-Ultrasound fusion and precision 3D biopsy (ProFuse/Artemis). He has many publication in the field of fusion and is part of active SBIR and R01 grants in this field. His contribution has helped improve the field of precision diagnostics for prostate cancer.

Satish Ramadhyani, Technical Lead, Systems Engineering, Galil Medical
As a Fellow at Galil Medical, Satish Ramadhyani has been involved in the design of cryoablation equipment. Among his contributions are the Visual-ICE console as well as several cryoprobes in Galil's product offerings. He was part of the design team that developed the Visual-ICE MRI system for performing cryoablation in MR suites. Satish retired recently but continues to serve as a consultant.

Franz Schmidlin, Head of Urology, Clinique des Grangettes, Geneva
Franz Schmidlin is a urological surgeon with a clinical activity in a private Hospital community in the Geneva region of Switzerland (Clinic des Grangettes) He also holds a teaching position as a Privat-Docent (Associate Professor) at the University of Geneva. His main interests are in urological oncology and he is particularly interested in the development of minimal invasive surgical techniques such as robotic surgery, endoscopic surgery and thermal therapies.

Yoed Rabin, Mechanical Engineering, Carnegie Mellon University
Dr. Yoed Rabin is a Professor of Mechanical Engineering at Carnegie Mellon University (affiliated since 1994). He has a broad range of research interests in the area of energy modalities in biology and medicine with current emphases on cryosurgery, cryopreservation, thermal ablation, interstitial photodynamic therapy, ultra-miniature implantable sensors, and thermal regulation in biological systems.

John Bischof, Mechanical and Biomedical Engineering, University of Minnesota
Bischof works in the area of thermal bioengineering with a focus on biopreservation, thermal therapy and nanomedicine. He is a Distinguished McKnight University Professor in the Departments of Mechanical and Biomedical Engineering, the inaugural Carl and Janet Kuhrmeyer Chair in Mechanical Engineering and the Interim Director of the Institute for Engineering in Medicine at the University of Minnesota.


Presentation Abstracts:

"MRI-Ultrasound Fusion Based Focal Cryosurgery"
MRI-Ultrasound fusion for prostate cancer diagnosis has seen wide spread success in early detection and localization of PCa. Devices such as the ProFuse/Artemis system has helped spread the utilization of such precision diagnostics to community hospitals and local urology groups. Now with better information and characterization of the lesion there is a need to provide truly focal treatment. Cryosurgery has long been studied and applied to the prostate since the 1970’s. Therefore it is the most understood energy source. This along with the fact that it is ultrasound visible provides the possibility to use cryo towards fusion based therapeutics.  The ProFuse/Artemis system has recently been used for focal cryosurgery and this technology will be presented.

"The Possibility of Focal Cryoablation of the Prostate Under MR Image Guidance"
MR imaging offers the possibility of focal ablation of malignant lesions in the prostate. With appropriate imaging sequences, the tumors can be clearly visualized and accurately targeted by percutaneously-placed cryoprobes. This talk describes a cryoablation system that was recently developed at Galil Medical for use in 1.5T and 3.0T MRI suites. The system has been approved for commercial use in the US and Europe.

"Focal Cryotherapy of Localized Prostate Cancer: A Work in Progress"
Recent progress in the detection of prostate cancer lesions within the prostate by MRI Imaging has opened new perspectives on both levels, diagnostic and therapy. Cryotherapy is one of the thermal energies that may be used as a surgical option for focal treatment. The objective of this presentation is to review our early clinical results with regard to oncological and functional efficiency and safety. Based on our experience we also outline our view for possible improvements of this technique from a clinical point of view.

"Computation Tools in the Service of Cryotherapy"
Cryosurgery is the controlled destruction of cancer tumors by freezing. This presentation reviews an array of computation tools developed for cryosurgery simulations, planning and training. Examples for the application of these tools are given for the special case of prostate treatment, where prostate cancer is the third leading cause of cancer death in American men.

"Adjuvants and Immunotherapy in Cryotherapy"
This talk will explore the use of cryosurgery to destroy tissue in situ by both cellular and host-mediated mechanisms. A particular focus will be to delineate destruction that is induced directly by the freezing and the enhancement of these mechanisms through adjuvants and immunotherapeutic approaches.


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