Cardiovascular 4: Cardiac Electrophysiology and Mapping
Wednesday, April 11, 9:00-10:30, A.I. Johnson Great Room, McNamara Alumni Center
Organizer: Bin He, Biomedical Engineering, University of Minnesota
"Electrophysiological Imaging of Cardiac Arrhythmias"
Bin He, PhD, Distinguished McKnight University Professor, Director, Center for Neuroengineering, University of Minnesota
"Optical Mapping of Voltage and Calcium in the Heart"
Alena Talkachova, Biomedical Engineering, University of Minnesota
"Cardiac Electrical Mapping Technologies for In Situ and In Vitro Research"
Michael G. Bateman, Department of Surgery, University of Minnesota
Session Abstract:
This session will consist of invited presentations on cardiac electrophysiology and mapping. Cardiac diseases represent significant public health concerns. Engineering approaches have been pursued for the purpose of better understanding the mechanisms of cardiac abnormalities using innovative mapping and imaging techniques. This session will provide an overview of state of the art of cardiac electrophysiological mapping and imaging, cardiac optical mapping and imaging as applied to the management of cardiovascular diseases such as arrhythmias.
Session Organizer Bio:
Bin He, PhD, Distinguished McKnight University Professor, Director, Center for Neuroengineering, University of Minnesota
Dr. Bin He is a Distinguished McKnight University Professor of Biomedical Engineering at the University of Minnesota, where he also serves as Associate Director for Research of Institute for Engineering in Medicine, Director of Center for Neuroengineering, Director of NSF IGERT Training Program in Neuroengineering, and Director of NIH Training Program in Neuroimaging. Dr. He's major research interests include neuroengineering and functional biomedical imaging. He has made significant original contributions to electrophysiological neuroimaging, multimodal functional neuroimaging, and brain-computer interface. Dr. He and his colleagues have pioneered the early development of anatomically constrained EEG source imaging and localization by means of the boundary element method, made significant contributions to novel methodologies of imaging oscillatory brain activity, and to the integrated EEG-fMRI neuroimaging methods. His lab has also made significant contributions to noninvasive EEG based brain-computer interface, and demonstrated for the first time the ability for human subjects to control flight of a virtual helicopter using noninvasive brain waves. Dr. He has published over 172 peer reviewed journal articles and delivered over 200 keynote, plenary and invited talks and seminars in international conferences and institutions worldwide. He served as the Past President of IEEE Engineering in Medicine and Biology Society, International Society for Functional Source Imaging, and International Society for Bioelectromagnetism. Dr. He is a Fellow of International Academy of Medical and Biological Engineering, IEEE, American Institute of Medical and Biological Engineering, Institute of Physics, and International Society for Functional Source Imaging.
Speaker Bios:
Alena Talkachova, Biomedical Engineering, University of Minnesota
Dr. Alena Talkachova is an Assistant Professor in the Biomedical Engineering Department at the University of Minnesota. Her research focuses on cardiac electrophysiology, aiming to investigate mechanisms of complex cardiac rhythms leading to ventricular fibrillation.
Michael G. Bateman, Department of Surgery, University of Minnesota
Michael Bateman obtained his master’s degree in Mechanical Engineering from the University of Bristol, UK. After a year in industry as a product design engineer he moved to Minnesota and is currently a fifth year PhD student in the Visible Heart® laboratory investigating the impact of transcatheter delivered valves on the local structural anatomy and electrophysiology.
Presentation Abstracts:
"Electrophysiological Imaging of Cardiac Arrhythmias"
Imaging myocardial activation is important for the study of mechanisms and for aiding in the management of arrhythmias. We will review our development of a novel electrophysiological imaging approach to noninvasively image cardiac activation from body surface potential maps. We have performed rigorous validation studies in rabbits, swine, and dogs to compare noninvasive imaging with endocardial mapping or intra-cardiac mapping. Our initial human data suggest the promise of this novel technology for aiding management of cardiac arrhythmias.
"Optical Mapping of Voltage and Calcium in the Heart"
Imaging electrical activity of the heart is important to understand its complex spatio-temporal dynamics, and to predict appearance of complex cardiac rhythms leading to ventricular fibrillation. However, electrical activity is bi-directionally coupled with the calcium giving rise to an excitation-contraction coupling in the heart. I will discuss simultaneous voltage-calcium optical mapping technique that can reveal complex interaction between voltage and calcium during normal and abnormal rhythms in the heart.
"Cardiac Electrical Mapping Technologies for In Situ and In Vitro Research"
The Visible Heart® laboratory employs cardiac electrical mapping technologies to investigate the generation of arrhythmias, the development of rhythm disease management systems and/or the effects of pharmaceutical anti-arrhythmic treatments. Non-contact endocardial mapping has been employed in both in situ and in vitro studies to visualize the electrophysiological effects of pharmaceutical and mechanical cardiac therapies. The laboratory also participates in the development of novel trans-mural mapping systems; both invasive research tools and non-invasive experimental clinical mapping systems.
Related Sessions:
Cardiovascular 1 Cardiac Keynote Presentations
Cardiovascular 2 Pre-Clinical Testing of Novel Cardiovascular Devices
Cardiovascular 3 Cardiovascular Modeling
Cardiovascular 5 Cardiac Ablative Therapies
Cardiovascular 6 Cardiac Devices in the Pediatric Population
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