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2012 Three-in-Five Competition

Wednesday AM Plenary Session, April 11, 7:15-8:45
Ballroom C, University Hotel Minneapolis


2012 Three-in-Five Winner Arvind Santhanakrishnan"Design, Development, and Validation of KIDS-CRRT - A Safe and Accurate Pediatric Continuous Renal Replacement Device"

Presented by Arvind Santhanakrishnan, Georgia Institute of Technology

Nearly 3,600 critically ill children per year with acute kidney injury receive life-saving continuous renal replacement therapy (CRRT) in the United States. However, there is no CRRT device approved by the Food and Drug Administration for use in pediatric patients. Thus, clinicians unsafely adapt adult CRRT devices for use in the pediatric patients due to lack of safer alternatives. These adult adapted CRRT devices operate with large extracorporeal blood volume relative to patient weight. Additionally, the adult CRRT devices provide inaccurate fluid balance with error in the range of 5-12% (based on expected output) between ultrafiltrate (UF) removal and replacement fluid (RF) infusion rates, leading to clinical complications. An unmet clinical need exists for a low extracorporeal volume, safe, accurate pediatric Kidney Injury and Dysfunction Support (KIDS) CRRT device.


2012 Three-in-Five Winner David Comber"Precision Pneumatic Robot for MRI-Guided Neurosurgery"

Presented by David Comber, Department of Mechanical Engineering, Vanderbilt University

Thermal ablation is an interventional technique that promises to enable percutaneous treatment of many cancers and other disorders throughout the human body. Acoustic ablation offers the possibility of steering thermal energy electronically, and is known to be MRI compatible, and thus amenable to real-time thermal dose monitoring through MR thermometry. We propose a pneumatically actuated robotic approach for delivering the ablator tip to a desired target, since a robot has the potential to be more accurate than humans, and can work within the confined space of a standard MRI machine. Our robot is designed to deliver a steerable needle made from precurved elastic concentric tubes.


2012 Three-in-Five Winner Massimiliano Simi"Magnetic Mechanism for Wireless Capsule Biopsy"

Presented by Massimiliano Simi, The BioRobotics Institute, Scuola Superiore Sant’Anna, Pisa, Italy. STORM Lab, Mechanical Engineering Department, Vanderbilt University, Nashville, TN

One of the main diagnostic limitations of current gastrointestinal (GI) capsule endoscopes is that they cannot get biopsies, thus requiring follow-up with flexible endoscopy whenever a suspicious lesion is identified. The ability of getting biopsies from a wireless capsule would save time and costs associated with the procedure, reducing at the same time invasiveness and discomfort for the patient. The Crosby capsule, designed in 1957, exploits a small tether to suck tissue, to activate spring-loaded knife and to manage device retrieval. However, invasiveness of the procedure is still relevant and requires sedation. Two compact mechanisms have been recently proposed for wireless biopsy. The first takes advantage of a spring actuated rotational razor, while the second exploits Shape Memory Alloy (SMA) to actuate a micro-biopsy spike. Due to the harsh environment of the GI tract and the absence of stabilization during sampling, both these devices have a limited efficacy. In order to improve efficacy while reducing capsule size, we propose a completely magneto-mechanical mechanism which does not require onboard batteries and actuators.


Panel Judges:

Ryan Egeland, MD, PhD, MBA, Rhode Scholar, Entrepreneur
Ryan Egeland is a medical and biotechnological innovator. He founded a DNA chip company with genetics pioneer Ed Southern which was acquired after he led a partnership with Sharp in Japan. He was recognized as one of the Top 100 Innovators in the World. He completed a surgical internship at Northwestern after graduating with honors from HarvardMedical School. He received a PhD in Biomolecular Engineering and an MBA from the University of Oxford where he was a Rhodes Scholar. He graduated from WayzataHigh School where he received the Westinghouse Scholarship for his early scientific research.

Danny Sachs, MD, Entrepreneur
Danny is a physician entrepreneur, founder of Respicardia, KSpine, and Mainstay Medical, all venture-backed device companies in the Twin Cities. He was previously a venture capital investor with Spray Partners and Investor Growth Capital, and served on the faculty of Harvard Medical School in the Division of Emergency Medicine.

Michael Hoey, MS, MBA, Entrepreneur
Michael is a former academic researcher at the University of Minnesota and now a full-time medical device innovator and entrepreneur. He founded Tsunami MedTech, an intellectual property and technology development company along with six medical products companies: Varix (now Veniti), Aegea, Fraqtal, Uptake, Venturix and NxThera. Additional companies founded on his technologies include Salient Surgical, Minnow Medical (now Vessix Vascular), and ASI.

Mike Hess, VP Innovation, Medtronic, Inc.
Mike Hess is the VP of Innovation for Medtronic focused on corporate technology and the establishment of regional R&D Centers. Mr. Hess has been at Medtronic for 21 years. He has a BS in Biomedical Engineering from Case Western and a MS in Software Engineering from the University of St. Thomas.

Randy Schiestl, VP R&D, Boston Scientific Corporation
Randall (Randy) Schiestl, PMP is the Vice President of Global Operations and Technology, Engineering Services Group at Boston Scientific where he leads a team to deliver computational analysis, design, engineering, packaging & labeling, customer focus, knowledge management and lab & test services for the corporation. He has BSME, MBA and Executive MBA degrees from the University of Minnesota. Randy received the UMAA Alumni Service Award from the College of Science & Engineering in 2011.

Reed Heimbecher, VP IP, St. Jude Medical 
Reed is the Vice President of Intellectual Property and Chief Patent Counsel for a division of St. Jude Medical where he leads a team of patent attorneys and support staff. He has practiced patent law for over 20 years in private practice; in the federal government; and, now, in-house. He has been with St. Jude Medical for the last 7 years with overall accountability for all aspects of his division’s worldwide intellectual property assets. Reed has a BS in Aerospace Engineering from the University of Colorado and a JD from the University of California, Hastings College of the Law.

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